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Home - Products - Membrane Transporter/Ion Channel - Beta Amyloid - LY 2389575 hydrochloride

LY 2389575 hydrochloride

CAS No. 885104-09-6

LY 2389575 hydrochloride( —— )

Catalog No. M33792 CAS No. 885104-09-6

LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 116 Get Quote
10MG 187 Get Quote
25MG 394 Get Quote
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Biological Information

  • Product Name
    LY 2389575 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.
  • Description
    LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease.
  • In Vitro
    Real Time qPCR Cell Line:Microglial cells Concentration:5 μM Incubation Time:1 h Result:Increased levels of Mrc1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Beta Amyloid
  • Recptor
    Beta Amyloid | GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    885104-09-6
  • Formula Weight
    438.58
  • Molecular Formula
    C15H16BrCl3N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (228.01 mM; Ultrasonic (<60°C); )Methanol : 8.33 mg/mL (18.99 mM; Ultrasonic (<60°C))
  • SMILES
    N(CC1=C(Cl)C=C(Cl)C=C1)[C@@H]2CN(CC2)C=3N=CC(Br)=CN3.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Caraci F, et al. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol Pharmacol. 2011 Mar;79(3):618-26.?
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